在农场长大可对哮喘和过敏免疫

Researchers at VIB (a leading life sciences institute in Flanders, Belgium) and Ghent University have successfully established a causal relationship between exposure to so-called farm dust and protection against asthma² and allergies³. This breakthrough discovery is a major step forward towards the development of an asthma vaccine⁴. The results of the research were published in the leading journal Science. It is commonly known that drinking raw cow's milk can provide protection against allergies. A 14-member research team, led by professors Bart Lambrecht and Hamida Hammad (both associated with VIB and Ghent University) has now established a solid scientific basis for this claim. 

 

Promising⁵ tests on mice

 

Many years ago, it was found that children growing up on farms are far better protected against asthma and allergies. However, until recently, scientists were unable to pinpoint⁶ why this is the case. 

 

Prof. Bart Lambrecht (VIB/Ghent University/Ghent University Hospital): "At this point, we have revealed an actual link between farm dust and protection against asthma and allergies. We did this by exposing mice to farm dust extract from Germany and Switzerland. These tests revealed that the mice were fully¹ protected against house dust mite⁷ allergy⁸, the most common cause for allergies in humans." 

 

Significant role of protein A20 

 

In addition to the causal relationship, the scientists discovered the mechanism⁹ behind this: farm dust makes the mucous¹⁰ membrane¹¹ inside the respiratory tracts¹² react less severely¹³ to allergens such as house dust mite. 

 

Prof. Hamida Hammad (VIB/Ghent University): "This effect is created by the A20 protein, which the body produces upon contact with farm dust. When we inactivate¹⁴ the A20 protein in the mucous membrane of the lungs, farm dust is no longer able to reduce an allergic¹⁵ or asthmatic reaction."

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