快乐的事情可能诱发心碎综合症

Happy events can trigger a heart condition known as takotsubo syndrome¹, according to research published today (Thursday) in the European Heart Journal. Takotsubo syndrome (TTS) is known as "broken heart syndrome" and is characterised by a sudden temporary weakening of the heart muscles that causes the left ventricle of the heart to balloon out at the bottom while the neck remains² narrow, creating a shape resembling a Japanese octopus³ trap, from which it gets its name. Since this relatively⁴ rare condition was first described in 1990, evidence has suggested that it is typically triggered by episodes of severe emotional distress⁵, such as grief, anger or fear, with patients developing chest pains and breathlessness. It can lead to heart attacks and death.

 

Now, for the first time, researchers have systematically⁶ analysed data from the largest group of patients diagnosed with TTS worldwide, and found that some patients have developed the condition after a happy or joyful⁷ event; they have named it "happy heart syndrome".

 

In 2011, Dr Christian⁸ Templin, principle investigator⁹ and consultant¹⁰ cardiologist, together with Dr Jelena Ghadri, resident cardiologist, established the first International Takotsubo Registry at the University Hospital Zurich in Switzerland. For this study they have analysed data from the first 1750 patients registered from the 25 collaborating¹¹ centres in nine different countries.

 

They found 485 patients where there was a definite emotional trigger. Of these, 20 (4%) had TTS that had been precipitated¹² by happy and joyful events, such as a birthday party, wedding, surprise farewell celebration, a favourite rugby team winning a game, or the birth of a grandchild; 465 (96%) had occurred after sad and stressful events, such as death of a spouse¹³, child or parent, attending a funeral, an accident, worry about illness, or relationship problems; one occurred after an obese¹⁴ patient got stuck in the bath. 

 

Ninety-five percent of the patients were women in both the "broken hearts" and "happy hearts" groups, and the average age of patients was 65 among the "broken hearts" and 71 among the "happy hearts", confirming that the majority of TTS cases occur in post-menopausal women.

 

Dr Ghadri said the new findings should lead to a paradigm¹⁵ shift in clinical practice. "We have shown that the triggers for TTS can be more varied¹⁶ than previously¹⁷ thought. A TTS patient is no longer the classic "broken hearted" patient, and the disease can be preceded by positive emotions too. Clinicians should be aware of this and also consider that patients who arrive in the emergency department with signs of heart attacks, such as chest pain and breathlessness, but after a happy event or emotion, could be suffering from TTS just as much as a similar patient presenting after a negative emotional event. Our findings broaden the clinical spectrum¹⁸ of TTS. They also suggest that happy and sad life events may share similar emotional pathways that can ultimately cause TTS."

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