改变蚊子的遗传基因可能控制寨卡病毒传播

Genetic² cues from male Aedes aegypti mosquitoes passed on during sex affect which genes³ are turned on or off in a females' reproductive tract⁴ post-mating, including genes related to blood feeding, egg development and immune defense⁵, according to new Cornell research. The researchers believe such processes provide information that could be exploited to fight mosquito-borne diseases, such as dengue fever, chikungunya and Zika virus.

 

"We have two main goals," said Laura Harrington, professor of entomology and a co-author of a paper published Feb. 22 in the Public Library of Science for Neglected Tropical Diseases. "The first is to understand the basic biology of the mosquito mating system, and the second is to try to understand it in a way that we can develop novel strategies for controlling the mosquito. We are focusing on reproduction because we see it as the Achilles heel of the mosquito."

 

The research draws from previous findings by molecular⁶ biology and genetics professor and study co-author Mariana Wolfner on how Drosophila females' gene¹ expression, behavior and physiology⁷ are changed by mating. That work revealed that after mating, seminal⁸ fluid proteins passed from males to females led to changes in gene expression in females and led females to increase egg production, reduce feeding and decrease their likelihood to mate again.

 

In this study, the researchers used sequencing to identify changes in RNA populations in the lower reproductive tract of female mosquitoes in response to mating. RNA is the chemical messenger by which the information in genes is translated into protein.

 

In the study, the researchers measured changes in the levels of specific RNAs in the female after mating to determine which proteins became more and less abundant. The findings are a step towards understanding what molecules⁹ are necessary to prepare a female for producing progeny¹⁰.

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