中国科学家绘制世界首张单细胞地图集

Chinese scientists have mapped the world's first single-cell mouse cell atlas¹ (scMCA).

 

中国科学家绘制出世界首张老鼠单细胞地图集。
 

 

The research, by a team from Zhejiang University, was published Friday in the Cell journal. Evaluation² experts from the journal said the research was of significance to the construction of the single-cell human cell atlas.

 

The scientists analyzed³ more than 400,000 single cells of mice using Microwell-seq, a high-throughput and low-cost scRNA-seq platform developed by the team, led by Guo Guoji. Guo said the technology would bring a methodological revolution to cell detection, taxonomy and identification.

 

Conventional technology for genetic⁴ sequencing analyzes⁵ cells group by group, and the specificity of each single cell may be neglected. However, the scMCA mapped by Microwell-Seq can clearly present the differentiation⁶, lesion and senescence of each single cell.

 

In recent years, single-cell sequencing technology has been widely used in the detection of tumor⁷ cells and prenatal diagnosis⁸ of embryonic⁹ cells.

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