中国科学家制造基因改良人类血管细胞

Chinese scientists produced the world's first genetically-engineered human blood vessel² cells, providing a promising³ option for therapeutic⁴ use.

 

中国科学家制造出世界第一个基因工程人类血管细胞，为相关治疗带来了希望。

 

The study published on Thursday in the journal Cell Stem Cell showed that human vascular⁵ cell function can be enhanced by editing a single longevity-related gene¹.

 

Scientists from the Institute of Biophysics of the Chinese Academy of Sciences (CAS), Peking University and the Institute of Zoology⁶ of CAS targeted a gene called FOXO3, an important regulator to delay cellular⁷ aging, resist stresses and enhance cardiovascular balance.

 

The technique can also resist the cells' transformation⁸ into tumors. The risk of tumor⁹ transformation used to be a major concern for the application of the gene-editing technology.

 

The researchers tested it in a mouse model with blood-shortage or ischemic injury and found that those cells promoted vascular regeneration and resisted tumor transformation both in vitro and in vivo.

 

They expected to use gene-editing strategies in the future to produce high-quality, safe human vascular cell grafts¹⁰ in a large-scale and standardized¹¹ manner.

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