裸鼹鼠对脑缺氧研究或有帮助

Blind, nearly hairless, and looking something like toothy（露出牙齿的）, plump（圆胖的，丰满的）, pink fingers, naked mole¹ rats（鼹鼠） may rank among nature's most maligned²（有害的，恶性的） creatures, but their unusual physiology³（生理学） endears（使受喜爱） them to scientists. Two University of Illinois at Chicago researchers report in the Dec. 9 issue of NeuroReport (now on-line) that adult naked mole rat brain tissue can withstand（抵抗，对抗） extreme hypoxia（缺氧，低氧）, or oxygen deprivation⁴, for periods exceeding a half-hour -- much longer than brain tissue from other mammals.

The findings may yield clues for better treatment of brain injuries associated with heart attack, stroke and accidents where the brain is starved of vital oxygen.

John Larson, associate professor of physiology in psychiatry⁵, and Thomas Park, professor of biological sciences, studied African naked mole rats -- small rodents⁶（啮齿类） that live about six feet underground in big colonies of up to 300 members. The living is tight and the breathing even worse, with the limited air supply high in carbon dioxide and low in oxygen.

The air they breathe is so foul⁷ it would be fatal or lead to irreversible（不可逆转的） brain damage in any other mammal, Larson and Park said.

But naked mole rats studied were found to show systemic hypoxia adaptations, such as in the lungs and blood, as well as neuron（神经元） adaptations that allow brain cells to function at oxygen and carbon dioxide levels that other mammals cannot tolerate.

"In the most extreme cases, naked mole rat neurons maintain function more than six times longer than mouse neurons after the onset⁸ of oxygen deprivation," said Larson.

"We also find it very intriguing⁹（吸引人的，有趣的） that naked mole rat neurons exhibit some electrophysiological（电生理学的） properties that suggest that neurons in these animals retain（保持，保留） immature¹⁰ characteristics."

All mammal fetuses¹¹（胎，胎儿） live in a low-oxygen environment in the womb（子宫）, and human infants continue to show brain resistance to oxygen deprivation for a brief time into early childhood. But naked mole rats, unlike other mammals, retain this ability into adulthood¹².

"We believe that the extreme resistance to oxygen deprivation is a result of evolutionary¹³ adaptations for surviving in a chronically¹⁴ low-oxygen environment," said Park.

"The trick now will be to learn how naked mole rats have been able to retain infant-like brain protection from low oxygen, so we can use this information to help people who experience temporary loss of oxygen to the brain in situations like heart attacks, stroke or drowning（溺水的）," he said.

Larson said study of the naked mole rat's brain may yield clues for learning the mechanisms¹⁵ that allow longer neuronal survival after such accidents or medical emergencies, which may suggest ways to avoid permanent human brain damage.