弥散张量成像可增强去除儿童良性肿瘤的能力

A new study published this week in the Journal of Neurosurgery神经外科杂志: Pediatrics小儿科 finds that operative plans for removing Juvenile¹ Pilocytic纤维状细胞的 Astrocytoma星状细胞瘤, or JPA, tumors in the thalamus神经床 of the brain can be augmented³ with Diffusion⁴ Tensor Imaging弥散张量成像, or DTI. The sensitivity of DTI imaging allows for the visualization⁵ of nerve fiber⁶ bundles in the brain. This information can maximize the potential of completely removing the tumor² while avoiding damage to the fiber bundles that are directly related to motor functions of the patient. "This study of six children with thalamic JPA showed that using advanced MRI technology can help identify distorted扭歪的 nerve fiber bundles around brain tumors," said Jeffrey H. Wisoff, MD, director of the Division of Pediatric Neurosurgery at NYU Langone Medical Center. "This allows an otherwise inoperable tumor to be completely removed which can hopefully lead to a cure."

Operating on patients with deep-seated tumors such as JPA, a benign⁷ tumor most frequently observed in children and young adults in the thalamus, remains⁸ a neurosurgical challenge. Conventional imaging techniques, such as structural⁹ MRI, has been revolutionary in helping¹⁰ to reveal major anatomical features解剖特点 of the brain, primary gray matter which is made up of nerve cell bodies. Diffusion Tensor Imaging, a variation of MRI, can help identify white matter, or nerve fiber bundles, using specific radio-frequency and magnetic field磁场 pulses脉冲 to track the movement of water molecules¹¹ of the brain. In most brain tissue, water molecules diffuse散播，传播 in all different directions. But they tend to diffuse¹² along the length of axons轴突，神经突, whose coating of white, fatty myelin髓磷脂 holds them in. Scientists can create pictures of axons by analyzing¹³ the direction of water diffusion.